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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T75119 | KRASG12C IN-2 | ||
KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1]. | |||
T36256 | LC-2 | LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 | PROTACs |
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recru... | |||
T80750 | YN14 | PROTACs | |
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). It exhibits antiproliferative effec... |